Good outcome in pregnant woman with diabetes insipidus; Case report and review article

Azar Danesh Shahraki, Azam Zafarbakhsh, Amirreza Farhadian Dehkordi


Polyuria is a common complication in pregnancy, but it should be distinguished from polyuria due to diabetes insipidus with low urinary osmolality. Diabetes insipidus (DI) can occur as primary, central and nephrogenic. Transient DI contributed to changes in pregnancy, especially in twin pregnancy or subsequent to preeclampsia, HELLP syndrome, fatty liver, hepatitis or cirrhosis (1-3). Sometimes the disease is sub-acute and it is less symptomized during pregnancy (4). Recognition and treatment of DI cause in pregnancy is important because the fluid restriction can lead to hypernatremia with major manifestations such as neurological symptoms including restlessness, weakness, decreased consciousness, delirium, seizures or coma.This condition has a mortality rate of around 40-55% and also reduce amniotic fluid volume which caused fetal stress. (5, 6).The present study introduces two cases of pregnant women with diabetes insipidus, who had timely and accurate control of symptoms in pregnancies, also healthy neonates were born. Now, one of them is pregnant for the third time. The purpose of this presentation is the management of high-risk DI pregnant patient, during the prenatal period, delivery and post-partum.


Danesh Shahraki A, Zafarbakhsh A, Farhadian Dehkordi A. Good outcome in diabetes insipidus pregnant woman; Case report and review article. Immunopharmacogenetics. 2020;3: e01


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